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That was clear from the start, on Simon & Garfunkels 1964 debut single, which announced the poets arrival with a lapel-grabbing opening line: Hello darkness, my old friend. In its way, The Sound of Silence was as forceful as two other landmark songs much played that same year: The Times They Are a-Changin and I Want to Hold Your Hand. Its stark sound registered generational disaffection

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Cancer risk Smoking mouth throat larynx esophagus stomach pancreas colon and rectum Type 2 diabetes Smoking also has an effect on insulin, making it more likely that youll develop insulin resistance